Basic Cuts by Designer Supplements

BASIC CUTS™

A Designer Stackables™ product by Designer Supplements

Introducing BASIC CUTS™, the first member of our Designer Stackables™ line of products. The intention of the

Designer Stackables™ catalogue is not to pioneer the innovative products that Designer Supplement has been celebrated

for in the past, but to provide cost-effective basic accompaniments to complement and enhance the efficacy

of other Designer Supplements products. The beauty of the Stackables, however, is that they will all bestow their own

credible results without stacking, and BASIC CUTS™ is no exception.

As expected from such an appropriately titled product, BASIC CUTS™ is a stimulating, thermogenic fat-burner that

will provide increased energy and increased metabolism in a cost-effective manner. While diet and cardio are still

the king and queen of fat loss, BASIC CUTS™ can be added as a stand-alone or in conjunction with Melting Point™

and/or Lean Xtreme™ to accelerate results.

In order to achieve a significant stimulatory effect without the inclusion of ephedrine, ephedra, or yohimbine, BASIC

CUTS™ utilizes a quartet of synergistic ingredients – Hordenine, Phenylethylamine (PEA), Caffeine and Cayenne

Pepper. While the profile of this product does not immediately scream the innovation typically expected of any product

linked to Designer Supplements, don’t be fooled - this is not just an average run-of-mill fat burner.

Phenylethylamine (PEA) is a naturally occurring neuroamine found in

foods such as chocolate as part of a compound called chocamine, which

is quietly gathering popularity in the bodybuilding community for stimulation

and fat loss. Due to increased urinary concentrations of phenylacetic

acid - a major metabolite of PEA1 - after exercise, it has

been theorized that PEA may be partly responsible for the “runners

high”, or post-lifting elation experienced by most weightlifters

or exercise enthusiasts2. PEA appears to exert a stimulatory

effect in the brain through its effect on the beta-adrenergic and

dopamine receptors, similar to antidepressants4. Through these

mechanisms, PEA not only increases attention and activity but

can also elevate mood significantly3. As anyone can see, these

effects can certainly lead to increased focus and motivation both

in the gym and in daily activities.

The major stumbling block for PEA is that oral bioavailability is

pitifully low. This is because PEA is quickly metabolised by the

enzyme Monoamine Oxidase B (MAO-B), so that very little, if

any, makes it to the brain. It has been suggested that one may

get around this by taking the amino acid phenylalanine (a PEA

precursor), however this does not guarantee significant concentrations

of PEA will be synthesised, let alone make it to the brain.

To every problem lies a solution, however, and this leads to the

introduction of another ingredient for BASIC CUTS™ - Hordenine.

The Monoamine Oxidases, MAO-A and MAO-B, are two enzymes

principally involved in catalyzing the oxidation (metabolism)

of the monoamines. MAO-A is commonly thought to break

down the neurochemicals serotonin and norepinephrine while MAO-B generally catalyzes the break down of dopamine

and PEA (as stated above). Hordenine is included in BASIC CUTS™ due to its ability to inhibit MAO-B5 and

thereby make PEA orally bioavailable thus allowing all the intriguing effects of stimulation and mood enhancement

mentioned above to become a reality. As a consequence of hordenine’s MAO-B inhibition, dopamine activity is also

prolonged. During dieting, dopamine is of particular importance because it is generally theorized to be the body’s

means of communication between the brain and the anti-starvation hormone Leptin. Additionally, dopamine is also

associated with nutrient partitioning (where the calories you consume go), mood, appetite and a whole host of other

biochemical functions. Unfortunately, when you diet, dopamine also happens to decrease quite significantly6, thus

some means of ensuring adequate dopamine output should be paramount (hint: hordenine helps).

BASIC CUTS™

A Designer Stackables™ product by Designer Supplements

As if its efficacy in increasing PEA availability and dopaminergic tone weren’t enough, there is also credible evidence

that hordenine not only “liberates” norepinephrine7, but also inhibits its metabolism8, leading to increased stimulation.

As many know, norepinephrine and epinephrine collectively form the catecholamines – the means through which the

popular supplement ephedrine indirectly exerts its stimulatory effect on the central nervous system and improves

lipolysis (fat burning).

Cayenne pepper is considered by many to simply be a “spice”, but in reality it is technically a berry known as Capsicum.

Heralded for its medicinal qualities, the cayenne pepper has historically been rubbed into the skin to provide

an analgesic numbing effect or taken orally to reduce intestinal problems and aid circulation with well documented

efficacy. With this in mind, it is surprising that while the herbal medicine market has begun to boom in recent years,

cayenne pepper appears to be one supplement overlooked by most.

Our interests in cayenne pepper as part of the BASIC CUTS™ formula lie in the properties that make it an incredibly

constructive tool for dieting. First, cayenne pepper rapidly boosts metabolic rate, as measured by oxygen consumption

and energy expenditure9, 10, 11. While the proposed mechanism for this effect is assumed to be through thermogenic

beta-adrenergic stimulation12, it is not clear whether this effect is direct or indirect and related to one of the

active constituents of capsicum, Capsaicin, and its promotion of catecholamine release13. Second, cayenne pepper

boosts carbohydrate oxidation during exercise and at rest13. Simply stated, more carbohydrate burning means more

calories are being burned - clearly a desired trait for shedding that excess weight. Finally, cayenne pepper also assists

in appetite suppression14, 15, something that can become a critical factor for even the most strong-willed dieter.

Under the radar or not, from these three effects alone one can see that even as a stand-alone compound, cayenne

pepper confers remarkable benefits for those attempting to lose weight. When combined with the other ingredients

found in BASIC CUTS™, however, cayenne pepper becomes much better...especially when considering cayenne

pepper’s synergistic quality for reducing food intake and increasing energy expenditure in combination with the final

ingredient in the profile – caffeine16.

Caffeine is one of the worlds most used (and in some cases abused) drugs, notably due to its inclusion in popular

beverages such as coffee, tea, soda and energy drinks and its presence in foods such as chocolate – all of which

form a “staple” of many a diet. While many consume these foods and beverages simply because they taste good,

a closer examination indicates that they may make you feel good, as well. Upon consumption, caffeine acts in the

brain by antagonising (blocking) adenosine A1 and A2A receptors17, 18, inhibiting the breakdown of Cyclic Adenosine

Monophosphate (cAMP).

Adenosine typically slows nerve cell activity, initiating a relaxed type of environment similar to the state experienced

during sleep. By antagonising adenosine, this effect is in fact reversed and nerve cell activity is increased. This

causes catecholamine release and central nervous stimulation that makes caffeine such a Godsend for those who

find mornings difficult. Adenosine also inhibits dopamine release, thus inhibiting adenosine can help maintain dopamine

signalling, which as explained earlier, is of the utmost importance.

While most users will testify that caffeine alone is a sound appetite suppressant, it appears that it has significant

effects in potentiating the effect of other stimulants19, 20. As already noted caffeine works well with cayenne pepper

to boost energy expenditure and while there is no direct evidence for it, many expect caffeine may also enhance

cayenne pepper’s effect on appetite suppression as well.

As far as performance is concerned, caffeine may not only help in delaying fatigue and allowing one to maintain training

intensity for a complete session21, but it may also assist strength training22 and help improve endurance, making

it a valuable compound to utilize for cardiovascular training which can further assist any fat loss endeavour23.

While individual tolerance may vary and dosing is up to the customer, BASIC CUTS™ can be used to assist fat loss

during dieting or as a pre-workout stimulant during bulking, particularly when stacked with the Designer Supplements

product, XCEED™. As anyone can see, calling a potent, cost-effective and very efficient formula BASIC CUTS™ is

slightly deceiving...this product is anything but basic.

BASIC CUTS™

A Designer Stackables™ product by Designer Supplements

Basic Cuts™, like all Designer Stackables™ products, is designed to be used in
conjunction with products from the Designer Supplements™ line. Basic Cuts™ is a stimulating, thermogenic fat-burner that will provide increased energy, an increased metabolism, and will be a cost-effective addition to any diet as a stand-alone or in conjunction with Melting Point™ and/or Lean Xtreme™.

• Designer Supplements Basic Cuts