SesaMAX� Lipo Incinerating Complex�

What is Sesamin
Sesamin is a lignan that is found in sesame seeds.  A lignan is a molecule that combines with a receptor to activate that receptor, and create a response.  The receptor and lignan will then perform a function in the body.  Sesamin is a lignan for the Peroxisome Proliferator-ActivatorReceptor Alpha (PPARalpha).  The receptor is found in muscle, liver, and heart tissue and is involved in the oxidation (burning) of fat.  Activation of PPARalpha increases gene expression of the fatty acid oxidation (burning) enzymes and decreases gene expression of lipogenic (fat storing) enzymes.  Sesamin has been shown to be a potent PPARalpha activator. The majority of fat oxidation occurs in skeletal muscle cells and the liver.  PPARalpha activation by sesamin increases fat oxidation by increasing the expression of enzymes involved in the oxidation of fatty acids.  SesaMAX� can increase some types of enzymes that help shuttle fatty acids into the mitochondria of cells, where they are burned.

Decreased fat storage
SesaMAX� is an amazing fat burning supplement for several reasons.  First, Sesamin has been shown to decrease the lipogenic (fat storing) gene expression of several different enzymes involved storing fat.  These enzymes include sterol regulatory element binding protein-1 (SREBP-1), acetyl-CoA carboxylase, and fatty acid synthase.  Decreasing these lipogenic enzymes means that less fat is esterifized in the liver and less fat is stored in the body.  Second, flax seed oil provides the essential fatty acids necessary to support optimal metabolism in the body.  Supplementing with essential fatty acids can actually help your body loose fat, decrease cholesterol and reduce oxidative stress. 

Ketosis
Ketogenesis occurs when fatty acid oxidation is increased to a point where the liver cannot metabolize the fatty acids completely. Excess acetyl-CoA (which can be created from glucose, fat or amino acid metabolism) is converted to ketones in the liver and released into the bloodstream for use by other tissues as fuel (specifically the brain).  Ketones are very important during a low carb diet, because the brain cannot use fatty acids for fuel.  The brain can use glucose, but when glucose is low, the brain will turn to ketones for its energy. Sesamin has been shown to increase ketone production. Increasing ketone production with Sesamin should have protein-sparing effect, because less amino acids will be needed to create ketones. The addition of flax seed oil to SesaMAX will also support ketogenesis and help you keep as much muscle as possible while dieting.  This means your muscle mass will be spared while dieting and you will loose more fat!

Other Benefits
SesaMAX� has other benefits in addition to promoting fat loss.  Both Sesamin and flax seed oil have been shown to act as antioxidants and provide liver protection against alcohol and improve liver function.  SesaMAX� can decrease cholesterol levels, while increasing high density lipoprotein (HDL aka "good cholesterol") levels.  Because of the benefits of flax seed oil and Sesamin, SesaMAX� can also act as an anti-inflammatory.

REFRENCES:
1. Akimoto K., et al. 1993.  Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann Nutr Metab. ;37(4):218-24.
2. Ashakumary L., et al. 1999. Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat. Metabolism. Oct;48(10):1303-13.
3. Fukuda N, et al. 1999. Effect of dietary sesamin on metabolic fate of an exogenous linolelaidic acid in perfused rat liver. J Nutr Sci Vitaminol (Tokyo). Aug;45(4):437-48
4. Hirose N., et al. 1991. Inhibition of cholesterol absorption and synthesis in rats by sesamin. J. Lipid Res. Vol 32, 629-638.
5. Ide T., et al. 2001. Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. Biochim Biophys Acta. Nov 30;1534(1):1-13.
6. Ide T., et al. 2003. Sesamin, a Sesame Lignan, as a Potent Lipid-Lowering Food Component. JARQ 37 (3), 151 - 158.
7. Ide T. 2004. Interaction of dietary fat types and sesamin on hepatic fatty acid oxidation in rats. Biochim Biophys Acta. Jun 1;1682(1-3):80-91.
8. Ogawa H, et al. 1995. Sesame lignans modulate cholesterol metabolism in the stroke-prone spontaneously hypertensive rat. Clin Exp Pharmacol Physiol Suppl. Dec;22(1):S310-2.
9. Utsunomiya T., et al. 2000. Effects of sesamin-supplemented dietary fat emulsions on the ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor in rats. Am J Clin Nutr. Sep;72(3):804-8.

Other Ingredients: Gelatin, Soybean Oil, Lecithin, Water, Glycerin.

Store In a cool, dry place. Protect from heat, light and moisture.

Recommended Use: As a dietary supplement, take one softgel 3 times daily with meals. Taking 2 softgels 3 times daily may provide greater benefit to those who tend to store body fat easily, or those who are consuming higher calorie diets as a way to prevent extra calories from storing as fat.

Warning: Keep out of reach of children. Always consult a physician prior to using any dietary supplement.

Manufactured with pride in the USA.

SesaMAX� is a registered trademark of Axis Labs.

• Sesamax