Fairly large doses of Arginine are required to enhance Nitric-Oxide (N0) production or stimulate insulin release. The majority of studies conducted with L-Arginine that relate to the benefits of Nitric-Oxide production or insulin-mediated vasodilatation have either involved intravenous administration or oral administration of immediate release formulations in repeated doses throughout the day. Single large dosages of Arginine are not well tolerated and may cause stomach discomfort and diarrhea. In a pilot study, subjects given 4 grams of L-Arginine freebase experienced bowel intolerance and diarrhea within a few hours. After a two-week washout, the same subjects were given the same 4-gram dose again with the same results. Diarrhea speeds up gastric emptying and shortens transit time for solutes in the window of absorption.
Surprisingly, when the same subjects were given TRT™ Arginine, greater absorption was possible due to reduced bowel intolerance. In this way less L-Arginine is lost to diarrhea, and more is absorbed for vasodilatation or production of nitric oxide. TRT™ not only increases the tolerated amount of oral dosages but also prolongs the supply of Arginine to stimulate insulin release.
MHP has discovered that by incorporating Arginine with Creatine, muscle Creatine stores can be increased. An even more effective formulation for accomplishing Creatine muscle transport and accumulation is the combination of (TRT™) time-release Arginine with (TRT™) time-release Creatine. Time-release Arginine is more effective because more Arginine substrate is made available through better absorption in the gastrointestinal tract. Therefore, more substrate is available for the production of nitric oxide mediated insulin, which stimulates better Creatine transport to and accumulation in muscle. Furthermore, by coupling the slow presentation of both substances simultaneously, a type of nitric oxide shuttle for more effective delivery of Creatine to muscle is provided.
By slowing down the rate of presentation of the Creatine to the liver and the muscles, especially during intense exercise or bodybuilding workouts, the need for normal Creatine loading, which is inefficient, is avoided. Instead, the supply of Creatine is constant, and is not working against a concentration gradient for entry to muscle. The slow, long term supply of Creatine, which spans many hours of exercise activity, provides a metered injection of Creatine as it is exhausted from muscle stores. This type of system is more effective during intense muscular activity than during sedentary periods because of the increased catabolism of Creatine to creatinine.
By slowing down the rate of increased substrate availability of a nitric oxide and insulin mediating substance such as Arginine, prolonged vasodilatation can be achieved. Instead of a sudden burst of nitric oxide and concomitant decay, long term conversion to NO or stimulation of insulin release can occur. Likewise, long term vasodialatory effect from insulin and a sustained increased in blood supply drives Creatine and other nutrient and energy rich co-factor availability to skeletal muscle. This increased blood flow and nutrient delivery to muscles can provide tremendous benefits to endurance athletes.
Nitric Oxide also functions as an anti-oxidant. Intense exercise increases production of reactive oxygen species (damaging free radicals). Creatine kinase, the enzyme responsible for conversion of Creatine to phosphocreatine (Creatine phosphate), is oxidized (inactivated) by free radicals. The anti-oxidant properties of nitric oxide enhancement via increased supply of supplemental L-Arginine should serve to extend and prolong the integrity of Creatine kinase, and thereby facilitate the cycling of Creatine to phosphocreatine. This should enhance Creatine stores in muscle cells, and provide a better environment for the entire process.
Aside from being the most advanced Creatine transport product ever developed, TRAC™ also provides many additional muscle building and physiological benefits. TRAC's™ time-released Nitro-Loading properties also improve the absorption of other nutrients. That's Right! TRAC's™ sustained production of Nitric Oxide can increase nutrient delivery (specifically amino acids) to working muscles. So, any other supplements you are taking, especially proteins, are going to be better utilized by the body. This is definitely an added bonus for bodybuilder and athletes.
I'm sure once other supplement companies learn of the amazing physiological effects of TRAC's™ Nitro-Loading; they will try to copy this extraordinary compound. However, TRAC's™ unique patent pending formulation and manufacturing process will prevent others from being able to copy this sophisticated technology.
