Venom Lean Dreams

Why Venom Lean Dreams™? Come on now, anyone who has experienced the fat loss and appetite modulating results from the new over-the-top energy phenomenon Venom Hyperdrive 3.0™ knows the need for a Night-Time Formula that will continue to modulate fat oxidation, yet support relaxation. You simply cannot stay wired 24/7.   Sleep and Natural GH Production!  Sleep is possibly one of the best natural tools for recovery we can maximize due to a very healthy increase in GH release, IGF-1 conversion and a period where glycogen stores can be replenished to a point of fueling tissue regeneration. Over half of our natural daily GH secretion occurs while we sleep….and we can produce more.  In short, we heal the damage we did during the day best while we sleep and burn fat for fuel (cool deal, huh?), if we can create the right environment.   There are a few problems, of course, that commonly hinder real progress in optimal fat loss and lean tissue retention during sleep:   1)     If we sleep too little, recovery sucks, GH release is blunted and fat accumulates. 2)     If we eat enough food to support full recovery, we hinder GH release and increase Insulin release…which means more fat storage while we sleep. 3)     If we eat too little we enter a catabolic state that does result in greater fat loss…but also results in hard earned lean muscle loss too. Why Is Healthy GH Modulation Paramount?  1)      GH is anti-catabolic meaning it protects against lean mass loss. 2)      GH facilitates recovery for hard working muscles, bones and connective tissue. 3)  GH increases fat oxidation and utilization as energy or for heat production.

What if We Could Modulate Fat Oxidation and Recovery …While aiding Relaxation? 

For many years hard-core athletes have used prescription drugs like Clonidine to increase nocturnal growth hormone release 200% and more. Though Clonidine is prescribed to treat high blood pressure (hypertension), misuse for GH stimulation and induced relaxation/sleep has been well noted. Though this has been reported as effective, it is dangerous as well. The use of anti-hypertension drugs when one has normal blood pressure can be disastrous.  

The key to this GH releasing/relaxation action is triggering the central cholinergic system, mainly through the presynaptic mechanisms.

Cortisol Eats Lean Tissue …and Promotes Fat Storage 

Several hormones and hormone-like-substances trigger catabolism or muscle wasting. Glucagon does so by setting into motion a series of metabolic events that result in the release of fatty acids, amino acids, and glucose/glycogen from body tissues to restore blood circulatory glucose and energy substrate levels. However, the group we are most concerned with are called corticosteroids or glucocorticoids.  

This is a group of steroids that originate at the adrenal cortex of the adrenal glands (above your kidneys). The most commonly discussed hormone of this group is cortisol. When a cortisol molecule merges with a muscle cell cortisol receptor-site, it triggers the release of amino acids from the cell. That probably does not sound like a big deal until you realize that these amino acids come from the breaking down of the muscle cell proteins. This of course means all of that hard earned lean mass tissue begins to waste away and become energy, heat or toilet trash.  

Cortisol levels are elevated as a result of stress. Unfortunately, the body views stress stimuli, such as increases in muscle tissue mass, training, sickness, dieting and the spouse or semi-spouse in a bad mood, as reason to increase circulatory cortisol levels. Cortisol production can also inhibit endogenous GH and testosterone production while fueling pathways that allow fat accumulation.  

Several studies have now validated that a main factor in fat storage (mostly around the waist and upper thighs) is increased cortisol production. As a result, the amount of fat we add to our waist daily can be favorably altered with a little control. Naturally, relaxation and sleep are paramount, but decreasing total cortisol production alone has a profound affect upon body composition.  

Oxidative Phosphorylation Uncoupler 

Normally, the mitochondria in our cells process do a process that converts ADP (adenosine diphosphate) into ATP (adenosine Triphosphate). As a rule the process is about 60% efficient, which means there is about 40% of the energy wasted. Now keep in mind that this “energy” is made food stores like fats, amino acids and glucose. When we exercise, this process accelerates and raises our metabolic rate. (More calories are burned as a result) The process is called oxidative phosphorylation.  

Since ATP is the high-energy chemical our bodies utilize for intense training, recovery and heat production, anything that compromises this process will make cellular mitochondria work harder and expend more energy as heat. (Body temperature rises) 

Some herbal extracts act as oxidative phosphorylation uncouplers. In doing so they make the process only about 40% efficient by uncoupling a high energy phosphate molecule from ATP and therefore turning ATP into ADP. To maintain an adequate supply of ATP, the body must step-up production.  

As a result resting metabolic rate is significantly increased and an incredible amount of calories are burned. During this accelerated metabolic state, and due to the need for ATP production, most of the calories come from fatty acids (adipose/fat tissue). So little or no muscle is lost…with adequate protein intake and proper GH modulation).  

Putting It All Together 

Venom Lean Dreams™ is uniquely designed to help us relax and sleep better while fueling the pathways that result in prioritized fat burning and lean tissue sparing recovery. Our goal is provide optimized results through optimized support and modulation of GH, Cortisol, Uncoupling of Oxidative Phosphorylation, rest and sleep.

What’s In Venom Lean Dreams™ and Why? 

Oleamide:  Endogenous sleep modulator
Tryptophane Ethyl Ester: Precursor to Serotonin, 5-HTP and melatonin.
Baicalin: Calming substrate, anti-anxiety and anti-cortisol
Jujube 2%: Used in folk medicine to promote restorative sleep.
Valerian: Calming agent and sleep aid.
Berberine: GH stimulation by way central cholinergic system, sleep aid/CNS depressant.
Hispidulin: GH modulation, anti-anxiety, uncoupler of oxidative phosphorylation and anti-oxidant.
Rotundine: Sleep augmentation and analgesic
Magnolia Extract: Cortisol inhibition and anti-anxiety support.
Melatonin: Master sleep hormone and anti-oxidant, cholinergic system protestant.
Piperine: Increases oral bioavailablity.

References: 

1) J Appl Physiol. 2006 Jan;100(1):120-8. Epub 2005 Sep 1.
Altered secretion of growth hormone and luteinizing hormone after 84 h of sustained physical exertion superimposed on caloric and sleep restriction.
2) J Endocrinol. 2005 Mar;184(3):481-92.
Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1.
3) The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):457-62. Epub 2003 Nov 13.
4) Effects of oleamide on choline acetyltransferase and cognitive activities. iosci Biotechnol Biochem. 2003 Jun;67(6):1284-91.
5) Biochemical regulation of non-rapid-eye-movement sleep. Font Biosci. 2003 May 1;8:d520-50. Review.
6) Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism. Free Radic Res. 2005 Dec;39(12):1305-15.
7) Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity. J Ethnopharmacol. 2005 May 13;99(1):145-6.
8) Flavonoids as superoxide scavengers and antioxidants. Free Radic Biol Med. 1990;9(1):19-21.
9) Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease. J Pineal Res. 2004 Sep;37(2):129-36.
10) The 24-h growth hormone rhythm in men: sleep and circadian influences questioned. J Sleep Res. 2004 Sep;13(3):251-5.
11) Journal of Clinical Endocrinology & Metabolism, Vol 62, 822-826, Copyright © 1986 by Endocrine Society Suppression of the growth hormone (GH) response to clonidine and GH- releasing hormone by exogenous GH

• VENOM LEAN DREAMS