Venom Special
Tactics™
Okay, now
that we have given you Venom Hyperdrive
3.0™ (you know the mega-energy-rapid
calorie expenditure phenomenon) and Venom
Lean Dreams™ (sleep/relaxation and
healthy GH modulator…because you can’t stay
wired 24/7) it is time to introduce the final
key to the Venom Tri-Lean System™
appropriately called…Venom
Special Tactics™.
Venom
Special Tactics™
is The highest standard by which
all other stimulant free adipose
inhibition and oxidation products should be
measured by. (As in…it inhibits fat storage and
aids burning the flab too) This new only from
ALRI product makes your body burn fat by wasting
calories at an accelerated rate while protecting
lean tissue mass and supporting thyroid
health….even while you are sitting on your butt!
(Imagine adding the Venom Tri-Lean™
training and diet system!) Venom Special
Tactics™ can be used alone, or stacked
with the rest of the Venom Tri-Lean™
System and Thyrogen-X™ for
Super Charged “I want it today” results.
What
makes this One Different from the Other ALRI
Venom™ Products?
Hey, it’s
from ALRI. You already know the innovation and
results will piss some wanna-be scientist off
because it is new, it works and they don’t
understand it.
Theobroma
Cacao extract for 12% OEA (oleoylethanolamide) and 3-Thia-Palmitic Acid (Tetradecylthioacetic
acid) are very cool compounds that promote
lipolysis (blubber burning) through some unique
pathways.
OEA is produced in the small
intestine and belongs to a group of fats
produced in response to nervous system activity
and certain metabolic events.
In an
interesting mammal study published in the
Journal of Biological Chemistry,
OEA was shown to reduce feeding and body weight
gain by activating the nuclear receptor PPAR-alpha
(peroxisome proliferator-activated receptor
alpha). In the present report, we examined
whether OEA can also influence energy
utilization. OEA stimulated glycerol and fatty
acid release from freshly dissociated rat
adipocytes. OEA enhanced fatty acid oxidation in
skeletal muscle strips, dissociated hepatocytes,
and primary cardiomyocyte cultures.
Administration of OEA in vivo produced lipolysis.
In short, the OEA study results
showed a decrease in food intake and an increase
in calorie expenditure by way of lipolysis and
fat oxidation through a unique pathway. The same
study left us with this quote to consider: “The
results suggest that OEA stimulates fat
utilization through activation of PPAR-alpha and
that this effect may contribute to its
anti-obesity actions”.
Then Why Add 3-Thia Palmitic Acid Too?
The
Department of Clinical Biochemistry, Haukeland Hospital, University of
Bergen, Norway did a study on 3-Thia fatty acids that resulted in
conclusions anyone wanting to create and maintain a lean body would
salivate over…
“The biological responses
to tetradecylthioacetic acid include mitochondrial proliferation,
increased catabolism of fatty acids, antiadiposity, improvement in
insulin sensitivity, antioxidant properties, reduced proliferation and
induction of apoptosis in rapidly proliferating cells, cell
differentiation and antiinflammatory action.”
“These biological responses indicate that tetradecylthioacetic acid
changes the plasma profile from atherogenic to cardioprotective. As a
pan-peroxisome proliferator-activated receptor ligand,
tetradecylthioacetic acid regulates the adipose tissue mass and the
expression of lipid metabolizing enzymes, particularly those involved in
catabolic pathways.”
Translation?
1)
Fat burning due to more mitochondria to do
so and fat oxidation via our good friend PPAR-alpha.
2)
Fat storage
control.
3)
Better insulin
activity control so calories are stored as lean tissue instead of waist
wrap for winter.
4)
Anti-oxidant
qualities to protect cells form the damage normally done by calorie
restricted diets and training.
5)
A cool hatred for
cells that are not supposed to be mass produced.
6)
Improved lipid
metabolization.
*So,
Together, OEA and 3-Thia Palmitic Acid make
for serious synergistic lipolytic action!
Cool, Now, How About Blocking Fat
Storage?
Polygonum
Multiflorum Proprietary Extract is one of the new sensations in the fat
burning industry. The really hard part is actually creating the most
effective proprietary extraction procedure to make it work and at a
concentration that makes it possible to put in a capsule.
Polygonum Multiflorum
Proprietary Extract has been used in herbal medicine for centuries for
its reported ability to promote lipid control and aid cardiovascular
health. Oh sure, there is a great deal of evidence that the extract acts
as an anti-oxidant, anti-catabolic and nitric oxide potentiator in
mammals, but more recently, and due to some pretty cool extraction
methods…
it has been found that
Polygonum Multiflorum Proprietary Extract has unique properties that
inhibit anti-lipolytic hormone (the hormone that shuts down fat burning
potential) and fatty acid synthase (the enzyme that is the gate keeper
for fat storage).
*As many fans of ALRI are aware, we love to use this and
the next compound in many of our fat loss lean mass promoting products
simply because they work so well.
Beta AET
ECPE (beta-androstenetriol ECPE)? We have all heard, and in many cases
experienced, the positive effects of DHEA and its even better
metabolites. As example are the patented and effective products
7-OXO-DHEA and of course 7-Hydroxy-DHEA analogs. They are noted for
their unique ability to avoid conversion into androgenic metabolites or
affect androgen receptors while promoting fat loss, lean mass retention
and even maximizing thyroid gland activity. Of course oral
bio-availability is pretty poor with most of these analogs thus
requiring higher dosages. Did I mention that bAET (b-androstenetriol) is
between 100 and 100,000 times more active than its DHEA precursor
metabolites? Okay, how about that bAET ECPE is nearly 100% orally
bioavailable? Yup. It’s why we formulated it.
Glucocorticoids in
humans are in two forms: Inactive cortisone and very active for eating
muscle cortisol. There are two enzymes that are able to make each of
these convert into the other.
11b-HSD-1:
Converts inactive cortisone into cannibalistic cortisol. Studies have
implicated this event in fat tissue as a pathway for increased fat
storage. Part of the reason GH has a positive affect upon body
composition is through its ability to inhibit 11b-HDS-1
11b-HSD-2: Converts
nasty cortisol into cortisone. 11betaHSD2
debunks intracellular cortisol by 90%. (Let the 11b-HSD-2 rule the
house)
Hmmm, more 11b-HSD-1 means more cortisol which eats more
muscle. And less means…Duh!
Beta-AET
ECPE inhibits the 11b-HSD-1 enzyme both locally and systemically. This
means that there is less conversion of cortisone to cortisol in muscle
as a result of training and everywhere else due to stress like dieting.
Based upon the studies, it appears that in mediating this pathway, bAET
ECPE increases immune function and recovery of cells as well. Add this
to its stimulatory affect upon the thyroid gland to support natural
thyroid hormone production? Yup, less cortisol, higher metabolic rate,
inhibition of that nasty negative thyroid hormone production feed-back
loop…less fat, more lean muscle and positive support to health. Not
bad!
Clary Sage Extract has a
really cool effect due to its cAMP stimulating value. There is a
significant similarity between compounds in this interesting herb and
Thyroid Stimulating Hormone (TSH). As most are aware, increased TSH
means more fat burning anabolism promoting T-3 production (yes, it acts
synergistically with the last goodie in this regard…but through
different pathways).
The connection here is
that the TSH-like effect triggers an enzyme called adenylate cyclase in
the thyroid that results in an increase in cAMP activity and
subsequently lots of extra T-3 production…naturally. Since there is an
increase in cAMP, there is an accompanying increase in nitrogen
retention.
What Else?
We added
Salvia Tanshinones to aid lipolysis via
improved liver lipid metabolism, gallic acid to inhibit fat cell uptake
of glucose, Oleanolic Acid to block fat absorption, Bergenin to enhance
norepinephrine triggered lipolysis and Rhodiola to support mood and
immune function.
What about Insulin
Insensitivity and Fat?
One reason we accumulate fat is
due to insulin. Insulin is likely one of the most anabolic to muscle
substances on the planet, but it has an evil side in that it is anabolic
to fat cells too. The reason is partitioning meaning that insulin can
store calories in fat or muscle.
As we gain fat, muscle cells
tend to become less sensitive to insulin (Insulin Insensitivity) and fat
cells tend to become ever so accommodating. So the result is that fat
get the lion’s share of calories coming in. When you diet or cut calorie
intake the muscle start to shrink and the fat cells have the upper hand
in the fight for calories which is why most lose more muscle than fat
when dieting.
The goal is to stimulate muscle
cell insulin sensitivity and decrease fat cell feeding frenzies…
Repartitioning!
Peroxisome proliferator-activated
receptor (PPAR)-gamma activators are widely used in the treatment of
type 2 diabetes because they improve the sensitivity of insulin
receptors. Punica granatum flower (PGF) has been used as an
anti-diabetic medicine in Unani medicinal literature. In several studies
the reported active compound in this friendly herb that causes this cool
event is gallic acid. You are already aware of the research that shows
gallic acid inhibits fat cell feeding on glucose, but the right
extraction has been shown in mammal studies to induce muscle cell
insulin sensitivity. When fat is starved and muscle is fed…well, you do
the math.
So
fat lipolysis with fat storage inhibition on multiple levels and
repartitioning to support lean tissue...now you get the “Special
Tactics” part?
WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE
OF 21 YEARS. DO NOT USE IF PREGNANT OR NURSING. KEEP OUT OF REACH OF CHILDREN. Do
NOT consume this product if you have a medical condition and/or taking any prescription
medication. Do not exceed recommended serving. Discontinue use and call a physician
or licensed qualified health care professional immediately if you experience rapid
heartbeat, dizziness, severe headache, or other similar symptoms. These statements have not been evaluated by the FDA.
This product is not intended to diagnose, treat, or
prevent any disease.
Research, Good Reading and References:
1) Oleoylethanolamide stimulates
lipolysis by activating the nuclear receptor peroxisome proliferator-activated
receptor alpha (PPAR-alpha). J Biol Chem. 2004 Jul 2;279(27):27849-54.
Epub 2004 Apr 26.
2) Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul
Integr Comp Physiol. 2005 Sep;289(3):R729-37. Epub 2005 May 5.
3) Effects of 3-thia fatty acids on beta-oxidation and carnitine palmitoylatransferase I activity in
cultured rat hepatocytes. Adv Exp Med Biol. 1999;466:53-7.
4) Metabolic effects of thia fatty
acids. Curr Opin Lipidol. 2002 Jun;13(3):295-304. Review.
5) Effect of guzhen recipe on glucocorticoid receptor in senile rate thymocyte] Zhongguo Zhong Xi Yi
Jie He Za Zhi. 1995 Feb;15(2):92-4. Chinese.
6) Effect of the root of Polygonum multiflorum Thunb. and its processed products on fat accumulation in the
liver of mice] Zhongguo Zhong Yao Za Zhi. 1992 Oct;17(10):595-6, 639. Chinese.
7) Traditional Chinese Medicine improves dysfunction of peroxisome
proliferator-activated receptor alpha and microsomal triglyceride
transfer protein on abnormalities in lipid metabolism in ethanol-fed
rats. Biofactors. 2005;23(3):163-76.
8) Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes.
Biochem J. 2005 Mar 15;386(Pt 3):471-8.
9) Carnosic acid, a new class of lipid absorption inhibitor from sage. Bioorg Med Chem Lett. 2004 Apr
19;14(8):1943-6.
10) Norepinephrine-augmenting lipolytic effectors from Astilbe thunbergii rhizomes. J Nat Prod. 1998
Aug;61(8):1006-11.
11) Huang TH, Peng G, Kota BP, Li
GQ, Yamahara J, Roufogalis BD, Li Y Anti-diabetic action of Punica
granatum flower extract: Activation of PPAR-gamma and identification of
an active component. Toxicol Appl Pharmacol 2005 Sep 1;207(2):160-9.
12) Arch
Pharm Res. 2003 Jan;26(1):24-7 Further isolation of antioxidative
(+)-1-hydroxypinoresinol-1-O-beta-D-glucoside from the rhizome of
Salvia miltiorrhiza that acts
on peroxynitrite, total ROS and 1,1-diphenyl-2-picrylhydrazyl radical.
Kang HS, Chung HY, Byun DS, Choi JS.
13) Am J Chin Med. 2002;30(1):87-93. Anti-hypertensive effect of water
extract of danshen on renovascular hypertension through inhibition of
the renin angiotensin system.Kang DG, Yun YG, Ryoo JH, Lee HS.
14) Phytother Res. 2003 Sep;17(8):917-20. Inhibition of angiotensin
converting enzyme by lithospermic acid B isolated from Radix Salviae
miltiorrhiza Bunge.Kang DG, Oh H, Chung HT, Lee HS.
15)J Ethnopharmacol. 2003 Oct;88(2-3):249-52. Anti-relapse properties of
IDN 5082, a standardized extract of Salvia miltiorrhiza, in alcohol-preferring rats. Serra S, Vacca
G, Tumatis S, Carrucciu A, Morazzoni P, Bombardelli E, Colombo G, Gessa
GL, Carai MA.
16) J Huazhong Univ Sci Technolog Med Sci. 2002;22(4):302-4. Effect of
Salvia Miltiorrhiza on left
ventricular hypertrophy and cardiac aldosterone in spontaneously
hypertensive rats. Han S, Zheng Z, Ren D.
17) Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Aug;22(8):607-9. Effect of
Salvia miltiorrhiza on
neuropeptide Y1-36 and calcitonin gene-related peptide in neonatal rats
with hypoxia-ischemic brain injury. Hong XR, Wu AQ, You ZD.
18) Antiviral Res. 2002 Jul;55(1):91-106. Isolation of two highly potent
and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1)
integrase from Salvia
miltiorrhiza. Abd-Elazem IS, Chen HS, Bates RB, Huang RC.
19) Arch Pharm Res. 2002 Aug;25(4):446-8. Inhibitory activity of
diacylglycerol acyltransferase by tanshinones from the root of
Salvia miltiorrhiza. Ko JS, Ryu
SY, Kim YS, Chung MY, Kang JS, Rho MC, Lee HS, Kim YK.
20) J Bioenerg Biomembr. 1999 Dec;31(6):559-67. Stimulation of
mitochondrial gene expression and proliferation of mitochondria
following impairment of cellular energy transfer by inhibition of the
phosphocreatine circuit in rat hearts.Wiesner RJ, Hornung TV, Garman JD,
Clayton DA, O'Gorman E, Wallimann T.
21) Acta Physiol Scand. 1998 Jul;163(3):251-9. Effect of chronic
electrical stimulation and beta-GPA diet on GLUT4 protein concentration
in rat skeletal muscle. Yaspelkis BB 3rd, Castle AL, Farrar RP, Ivy JL.
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