The Most Innovative Fat Burner Everﾅ..And This Time Itﾒs For Real!
It has been a couple of years since our ally in fat loss, ephedra, was forced off of the market. Since then, we have been fed false promises by companies saying that they have found the next ephedra, or made ephedra obsolete, orﾅ..you get the point. The bottom line is that when it comes to fat loss and energy, these products let you down. In fact, they might have let you down so much that you still buy ephedrine HCl and stack it with these so-called fat burners.
The Scivation team has been working hard to formulate the dream fat burner. Then one day, Scivation Advisory Board Member, Biochemist and Natural Bodybuilding Pro Layne Norton presented Scivation Director of Research & Development Chuck Rudolph with a compound with such impressive data that along with Derek Charlebois, they began immediately working. What came about was perhaps the ultimate fat burner.
This is a fat burner that does everything you need it to and not only helps you shed fat like crazy and provides energy beyond belief, but also has a myriad of other benefits. Layne Norton, one of the main researchers behind the Dialene 4 project, states, ﾓThe compounds present in Dialene 4 have multi-faceted positive impacts on body composition and health. Dialene 4 contains compounds that increase the liberation of free fatty acids from stored bodyfat and contains ingredients that increase the oxidation of those fatty acids, leading to an increase in the rate of fat breakdown.
This might sound too good to be true and the research points to these conclusions, but what happened when we actually tried the product? Scivation Research & Development team member Derek Charlebois was lucky enough to test Dialene 4 out and was blown away by what he and the Scivation team had discovered. ﾓMy experiences with Dialene 4 have been outstanding. The first time I took Dialene 4 I noticed an increase in heart rate, body temperature, sweating, and a greater pump in the gym (perhaps due to increased blood flow). I also experienced an almost euphoric energy high and enhanced focus in the gym. There was no crash in energy and I did not feel burned out once Dialene 4ﾒs effects wore off. Dialene 4 packs a serious punch and definitely gets your metabolism kickinﾒ!
But the main thing to overcome was delivery. How could Scivation take these innovative compounds, like the components of the LipoLeanﾙ Blend, and make it so everyone could reap the full benefits of this wonder-supplement? Team Scivation got to work. Using a patent-pending delivery system known as Sci-Capsﾙ, Scivation was able to reap the benefits of the G4 Fat Incinerating Matrix, the CogniLeanﾙ Blend and the LipoLeanﾙ Blend and deliver them quickly and effectively. ﾓWe feel that no one will be able to mimic this product for a very long time. With these compounds, proper delivery is crucial. This is where Scivation stands alone, says Marc Lobliner, President of Scivation.
The man behind the project, Chuck Rudolph MEd, RD, has put countless hours into this project designing Dialene 4 and perfecting the Sci-Cap delivery system. Chuck is very excited to launch Dialene 4, stating, ﾓI am excited to finally release Dialene-4. This project has taken us quite some time to develop and has involved countless hours of research and development. The total formulation along with the G4 Fat Incinerating Matrixﾙ and its effect on noradrenaline, as well our patent-pending Sci-Cap delivery technology, is assured to deliver a great energy burst as well as assist in fat burning.
If you want fat loss you can feel, look no further than Scivation Dialene 4. For those of you looking for some science and a background of the advanced Dialene 4 formula, read on. Dialene 4 could very well be your ticket to the body of your dreamsﾅ.
Stored TriglyceridesﾗBody Fat We Want to LOSE
While all cells contain some fat, it is mainly stored in muscle (intramuscular triglycerides) and in adipose tissue (body fat). Adipose tissue is the bodyﾒs main fat storage site.
Adipose tissue is divided into individual cells called adipocytes. These adipocytes hold stored triglyceride (1 glycerol molecule bonded to 3 fatty acids) droplets, which serve as a source of energy for the body. These droplets make up 95% of adipocytes volume. In order for this storage of potential energy (60,000-100,000 kcal) to be used and to LOSE BODYFAT (everyoneﾒs goal), it must be mobilized through lipolysis.
Lipolysis involves hydrolyzing (splitting with water) the triglycerides into a glycerol molecule and 3 separate fatty acids (FFA). This reaction is catalyzed by the enzyme hormone-sensitive lipase (HSL):
Triglyceride + 3 H2O ▬HSL Glycerol + 3 Fatty Acids
Once the fatty acids diffuse (exit) from the adipocytes, they bind to plasma albumin (a protein in the blood) in order to be transported to active tissues where they can be burned. In order to lose body fat, the fatty acids must be burned!
Transport of FFA to be Burned
Blood flow is of prime importance to the transportation of FFA away from adipocytes and through the circulation to active tissues. This is especially important during exercise where energy requirements are heightened.
Low blood flow could cause the accumulation of FFA within adipose tissue (Coppack et al 1994) resulting in less available FFA to be oxidized and a greater chance of FFA re-esterification into triglycerides. Increasing blood flow throughout the body will assist in losing weight by transporting FFA to where they can be burned.
FFA OxidationﾗBurning Body Fat
When the albumin-FFA complex reaches muscle tissue, the FFAs are released and are transported into a muscle cell. Once in the muscle cell, the FFAs can re-esterfy (rebind) with glycerol to form triglycerides or bind with intramuscular proteins to be used for energy production in the mitochondria.
In the mitochondria, the fatty acids undergo beta-oxidation. During beta-oxidation, fatty acids are converted to acetyl-CoA. Once the entire fatty acid molecule is degraded into acetyl-CoA molecules, they are sent into the citric acid cycle. ATP (the bodyﾒs main energy source) phosphorylates this reaction, then water is added, and the H+ are passed to NAD+ and FAD to be sent to the respiratory chain to be oxidized to create more ATP.
Beta-Oxidation is an aerobic reaction because oxygen is needed to bind with the H+. Remember, without oxygen, the H+ stay bound to NAD+ and FAD and the respiratory chain cannot transfer electrons and NADH and FADH2 levels accumulate, which stops fatty acid catabolism.
The water-soluble glycerol molecule formed from lipolysis can diffuse from the adipocytes into the circulation. The liver can use the glycerol in the circulation to form glucose through gluconeogenesis. Glycerol is accepted as 3-phosphoglyceraldehyde, which degrades to pyruvate to be oxidized for ATP in the citric acid cycle. The H+ are accepted by NAD+ and sent to the electron transport chain.
Glycerol also has a gluconeogenic role as it provides carbon skeletons for glucose synthesis. When glycogen levels are low or depleted, glycerol can serve as an important fuel source, which is important when dieting to lose body fat since calories will be decreased.
All of the above may seem like a lot of scientific mumbo-jumbo, but it is the basis around which Scivationﾒs new fat burner Dialene 4 was created. Now we will show you how Dialene 4 works to increase fat loss!
The ingredients in Dialene 4 work synergistically to increase Adrenaline output. The term ﾓadrenaline is commonly used to refer to the bodyﾒs excitatory catecholamine, Epinepherine (E) and Norepinepherine (NE) (Dopamine being the third catecholamine), which are regulators of lipolysis.
The sympathetic nervous systemﾒs postganglion neurons release NE as their neurotransmitter. When large amounts of NE are produced during times of stress, it can ﾓspillover into the blood and act on receptors throughout the body. Catecholamines can act on adipose tissue via direct sympathetic innervations or the general circulation (Coppack et al 1994).
Catecholamines act on the alpha (1 and 2) and beta (1, 2, and 3) adrenoreceptors throughout the body, with E having a greater affinity for the beta-receptors and NE for the alpha-receptors. Activation of the alpha1 and beta-receptors is lipolytic (causes fat breakdown) while activation of the alpha2 receptor is anti-lipolytic (blunts fat breakdown).
At rest, plasma catecholamine levels are low, causing the lipolytic rate to be regulated by the inhibitory action of the alpha2-receptors (Horowitz 2003). During exercise, the large increase in catecholamines causes the activation of the beta-receptors to override the alpha2-receptor inhibition of lipolysis and whole body lipolysis increases. This is where Dialene 4 comes into play. Using Dialene 4 during the day when plasma catecholamine levels are low allows you to overcome the inhibitory action of the alpha2-receptors and stimulate lipolysis (fat breakdown). Dialene 4 accomplishes this by increasing NE release and keeping NE levels elevated.
Norepinephrines (NE) Role in Lipolysis
1. NE release from synaptic nerves
2. NE binds to beta-adrenergic receptors
3. Stimulatory guanine nucleotide regulatory proteins (G-proteins) within the cell membrane activate the enzyme adenylate cyclase
4. Adenylate cyclase converts ATP into 3'-5' camp Cyclic AMP phosphodiesterase (PDE) halts this step Prostaglandins have receptors coupled to inhibitory G proteins (Gi), which decrease adenylate cyclase activity and thus decrease cAMP concentrations in the cell.
When a beta-adrenergic agonist such as NE stimulates a fat cell it produces adenosine. Adenosine interacts with its receptor coupled to regulatory G proteins (Gi) which inhibits adenylate cyclase activity and prevents the accumulation of cAMP
5. cAMP binds to the regulatory subunit of protein kinase A
6. Protein kinase A releases its catalytic subunit
7. The catalytic subunit phosphorylates Hormone Sensitive Lipase (HSL), transforming it into the active form, HSL-P
8. HSL-P catalyzes a three step hydrolysis reaction to reduce triglycerides into glycerol and fatty acids
Re-esterification can occur (Lipogenesis)
A summary of the above scientific jargon is NE increases lipolysis, which is vital to fat loss.
Dialene 4 Ingredients
Nutrition FactsServing Size 2 Tabs
Servings Per Container 45
|Amount Per Serving|
|Vitamin B12 (Methylcobalamin)||100 mcg||1667.000%|
|Vitamin B5 (Pantothenic Acid)||25 mg||250.000%|
|LipidOX Blend||550 mg||-|
|Vitamin B6 (Pyriodoxine HCl)||50 mg||1250.000%|
|The G5 Fat Incinerating Matrix||685 mg||-|
LipidOX Blend: PolyphOrac Blend Containing: Astanthanthin (1%), Fuco Xanthin (10%), Grape Skin Extract, Blueberry Extract, Raspberry Powder, Cranberry Powder, Prune Powder, Cherry Powder, Bilberry Extract, Strawberry Powder, Broccoli Cruciferous Extract, Spinach Powder, Tomato Powder, Carrot Powder, Onion Powder
The G5 Fat Incinerating Matrix
USP Caffeine, Cayenne Pepper (40,000 HU), Hordinine HCl, Synephrine HCl, Vinpocetine
|*percent Daily Values are based on a 2,000 calorie diet.|
Ingredients: Calcium Phosphate, stearic acid, croscarmellose sodium, silicon dioxide, magnesium stearate, F&DC red #4, Titanium dioxide, riboflavin, and methocellulose.Gelatin, Rosemary, D-Alpha Tocopherol Acetate.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
†Nutrition Facts are a simulation of the product's "Nutrition Label". For the actual Nutrition Label please refer to the product packaging.