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SUP3R EPI • Olympus UK

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$48.99
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60 caps
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SUP3R EPI

Olympus UK

 

Sup3r EPI Benefits


-Non-Methylated/Non-Liver Toxic (Doesn't require liver support such as TUDCA or NAC)
-Dry Compound/Non-Aromatizing (Won't convert estrogen nor cause water retention or bloating)
-Anti-estrogenic Effect
-Increases Aggression
-Increases Energy/Combats Lethargy
-Increases Muscle Hardness and Density
-Increases Strength via CNS Activation
-Increases Vascularity
-Reduces Water Weight (Leading to a drier/tighter appearance)
-Supports Libido
-Excellent for Cutting/Recomping
-Excellent Stacker

 

What is Sup3r EPI

Epiandrosterone is a precursor/prohormone to the androgen Dihydrotestosterone (commonly abbreviated to DHT) through a two-step conversion process in vivo by the enzymes 3ß-hydroxysteroid dehydrogenase (3ß-HSD) and 17ß-hydroxysteroid dehydrogenase (17ß-HSD). According to data from Julius Vida when Epiandrosterone is injected it is almost entirely inactive, resulting in only a very mild androgenic effect and must be taken orally to convert to an active hormone. There are two possible pathways of conversion, both requiring two conversion steps each to transition from Epiandrosterone to DHT. One conversion pathway for Epiandrosterone is to be converted by 3ß-HSD into Androstanedione (5a-androstane-3,17-dione) and then converted by 17ß-HSD into DHT. And another conversion pathway for Epiandrosterone is to be converted by 17ß-HSD into Androstanediol (5a-androstane-3b,17b-diol) and then converted by 3ß-HSD into DHT. It is quite difficult to calculate percentages for conversion rates due to the fact that these conversions are reversible, as Epiandrosterone can convert to DHT, and DHT can also convert to Epiandrosterone.

Whichever pathway Epiandrosterone takes in vivo, we arrive at the target hormone Dihydrotestosterone. And this is what makes Epiandrosterone interesting, as DHT is typically synthesized in the prostate, testes, hair follicles, and adrenal glands by the enzyme 5a-reductase which reduces the 4,5 double-bond of the hormone Testosterone. So what is DHT? Dihydrotestosterone (DHT), also referred to as 5a-Dihydrotestosterone (5a-DHT), Androstanolone (5a-androstan-17ß-ol-3-one) or 17ß-hydroxy-5a-androstan-3-one, is a naturally occurring sex steroid and androgen hormone in the human body. It has two to three times greater androgen receptor affinity than Testosterone and 15-30 times greater affinity than adrenal androgens. It plays a significant role in the development of secondary sex characteristics and unlike Testosterone it cannot be converted by the enzyme aromatase to estradiol.

It is more androgenic than it is anabolic, with claims of an anabolic/androgenic ratio of 152/268. In fact, it exhibits relatively little direct anabolic effects on muscle in men, with Testosterone being the primary active androgen in muscle. That is not to say DHT is without any anabolic effect, it does have some anabolic activity in the muscle, but such anabolic activity is significantly weaker than that of an equal amount of Testosterone. This is due to its quick breakdown by an enzyme called 3alpha-hydroxysteroid reductase (3a-HSD) into the weak metabolite 3a-androstanediol (5a-androstane-3a,17ß-diol), thus why it is not an effective anabolic in muscle tissue. But despite the fact that Epiandrosterone's target hormone has little direct anabolic effect on its own, DHT is still very important as it has potent effects on the central nervous system. These effects lead to increased neurological efficiency (increased strength) enabling you to lift more weight, and increased resistance to psychological and physical stress, as well as optimal libido and sexual function such as improved duration of erections and frequency of orgasms. This allows for higher intensity workouts that when paired with a proper diet and exercise program should allow for increased muscle mass.

 

It is possible that Epiandrosterone may cause some HPTA suppression, and therefore it is always recommended to run a properly planned Post-Cycle Therapy (PCT) following any supplementation regimen containing Epiandrosterone.

It is also worth noting that Epi-Andro, just as with 1-Andro and 4-Andro, undergoes significant first-pass metabolism in the liver. This, in addition to other factors, contributes to the low bioavailability of Epi-Andro. There are many delivery systems that have been utilized in attempts to enhance bioavailability, with the most recent advancements being with the pharmaceutical delivery system commonly abbreviated as S-SEDDS which stands for Solid Self-Emulsifying Drug Delivery Systems. S-SEDDS enhances absorption via the intestinal lymphatic system which circumnavigates the destructive hepatic first-pass metabolism.

 

In the world of supplementation, Andros reign supreme as today's legal prohormones of choice. For those who are unaware of these compounds, the term Andro specifically pertains to the naturally occurring DHEA metabolites known as Epiandrosterone, 1-Androsterone and 4-Androsterone. There are a wide variety of Andros available utilizing different delivery methods, each with claims regarding improved bioavailability, half-life, and so on. It can be confusing, even overwhelming, when trying to choose a product that meets your needs. So let's try to clear up some of that confusion by reviewing a few of the different delivery methods currently available.

 

Sup3r EPI Delivery System

SEDDS have been proven in the last two decades to be a phenomenal success. They are able to overcome some of the biggest challenges confronting contemporary delivery science today by improving on the oral bioavailability of compounds with poor and inconsistent gastrointestinal absorption. SEDDS do so by facilitating absorption of compounds via the intestinal lymphatic system and thus circumnavigating the hepatic first-pass effect. The lymphatic system is a drainage network that extends throughout the entire body in proximity to the circulatory system and is a logical target since orally administered compounds can work more effectively when transported selectively to the intestinal lymphatic system. The bioavailability of compounds that undergo significant first-pass metabolism in the liver, as Andros do without enhanced delivery methods, can be improved dramatically by utilizing the lymphatic system for absorption in the intestine, thus avoiding the destructive first-pass effect in the liver.

 

However SEDDS are typically prepared in a liquid form, which can result in some disadvantages, for example, low stability, large volume of dose and issues with handling and portability. To overcome these issues, solid-SEDDS (S-SEDDS) has emerged to improve upon an already excellent delivery system. Through solidification of liquid self-emulsifying systems into powders the liquid SEDDS can be converted into solid dosage form without affecting compound release property. Thus, S-SEDDS combines the advantages of SEDDS (i.e., enhanced solubility and bioavailability) with those of solid dosage forms (e.g., high stability and reproducibility, compact dosage form and ease of handling and portability). Though it has little, if any, current presence in the world of supplementation, S-SEDDS is a cutting edge and highly effective delivery system utilized by the pharmaceutical industry. It is without a doubt one of the most effective means by which to deliver any compound at this point in time, and stands to replace other more antiquated methods delivery in the very near future.

Sup3r EPI Example Cycles:
Beginner:
Epi-Andro – 500/500/500/500/500/500
*Space capsules out with meals containing fats.

Advanced/Experienced:
Epi-Andro – 500/500/750/750/1000/1000
*Space capsules out with meals containing Fats.
Epi-Andro – 1000/1000/1000/1000/1000/1000/1000/1000
*Space capsules out with meals containing fats.

Post Cycle Therapy (PCT):
Olympus Labs Sup3r PCT (As indicated on label)
AI of choice on hand (E.g. AR1MACARE PRO)

Andros also have synergy, when stacked together. Here are a few example stack cycles…

Ultimate Epi/4 Cycle:
Epi-Andro – 1000/1000/1000/1000/1000/1000/1000/1000
4-Andro – 330/330/330/330/330/330/330/330
*Space capsules out with meals containing fats.

Dry Epi/1 Cycle:
Epi-Andro – 1000/1000/1000/1000/1000/1000/1000/1000
1-Andro – 330/330/330/330/330/330/330/330
*Space capsules out with meals containing fats.

Elite Cycle:
Epi-Andro – 1000/1000/1000/1000/1000/1000/1000/1000
1-Andro – 330/330/330/330/330/330/330/330
4-Andro – 330/330/330/330/330/330/330/330
*Space capsules out with meals containing fats.

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